UCSF GI DIVISION FACULTY

James C. Ryan, M.D.

Associate Professor of Medicine in Residence
Veterans Affairs Medical Center

Address:

VAMC 111-R
Veterans Affairs Medical Center
San Francisco, CA 94121

Email:

Active Projects:

Characterization of a new family of natural killer lymphocyte receptors implicated in the recogniton and lysis of neoplastic, foreign, and virally infected cells.

Techniques in Use:

  1. Molecular characterization of receptor-ligand interactions and activation pathways.
  2. Protein-protein interactions, transmembrane signaling, eukaryotic and prokarytic protein expression and mutagenesis.
  3. Gene discovery through eukaryotic expression cloning and eukaryotic complementation.
  4. Monoclonal antibody production.

Recent Publications:

Kveberg L, Ryan JC, Rolstad B, Inngjerdingen M. Expression of regulator of G protein signaling proteins in natural killer cells, and their modulation by Ly49A and Ly49D. Immunology 2005; 115:358-65.

Naper C, Dai KZ, Kveberg L, Rolstad B, Niemi EC, Vaage JT, Ryan JC. Two structurally related rat Ly49 receptors with opposing functions (Ly49 stimulatory receptor 5 and Ly49 inhibitory receptor 5) recognize nonclassical MHC class Ib-encoded target ligands. J Immunol 2005;174:2702-11.