UCSF GI DIVISION FACULTY

Timothy Davern, M.D.

Adjunct Assistant Professor of Medicine, UCSF

Address:

Box 0538, UCSF

Email:

tim.davern@ucsf.edu

Active Projects:

Novel Methods of Gene Therapy for Liver Disease:
  1. Development of adeno-associated vectors for treatment of metabolic diseases of the liver,
  2. In vivo selection.
Acute Liver Failure Study Group:
  1. Define epidemiology of acute liver failure in the US,
  2. Double-blind study of n-acetyl cysteine (NAC) for non-acetaminophen acute liver failure.
Hepatotoxicity Clinical Research Network:
  1. Define the epidemiology and clinical characteristics of drug-induced liver injury;
  2. Pharmacogenomics.

Techniques in Use:

  1. Recombinant DNA technology.
  2. Cell Culture.
  3. Protein expression and purification.
  4. Viral vector production.
  5. Animal studies.

Recent Publications:

Davern TJ 2nd. Measurement of serum acetaminophen-protein adducts in patients with acute liver failure. Gastroenterology. 2006 Mar;130(3):687-94.

Wai CT, Fontana RJ, Polson J, Hussain M, Shakil AO, Han SH, Davern TJ, Lee WM, Lok AS; The US Acute Liver Failure Study Group. Clinical outcome and virological characteristics of hepatitis B-related acute liver failure in the United States. J Viral Hepatol 2005 Mar;12(2):192-8