UCSF GI DIVISION FACULTY

Laura Bull, Ph.D.

Associate Professor of Medicine
SFGH

Email:

lbull@medsfgh.ucsf.edu

Active Projects:

1. Screening of the FIC1 and BSEP genes for mutations leading to hereditary cholestasis.
2. Study of the relationship between phenotype and genotype in patients with inherited liver disease.
3. Identification of the gene mutated in hereditary cholestasis with lymphedema.
4. Identification of genetic factors influencing susceptibility to cholestasis of pregnancy.
5. Genetic studies of familial hypercholanemia.
6. Study of mouse models of hereditary cholestasis.

Techniques in Use:

1. Mutation screening using DNA sequencing and DHPLC;
2. gene mapping and cloning using genotyping of microsatellite DNA markers;
3. generation and study of mouse models of hereditary liver disease, disease gene identification using database mining and gene identification programs.

Recent Publications:

Groen A, Kunne C, Paulusma CC, Kramer W, Agellon LB, Bull LN, Oude Elferink RP. Intestinal bile salt absorption in Atp8b1 deficient mice. J Hepatol. 2007 Mar 7

Bull LN, Mahmoodi V, Baker AJ, Jones R, Strautnieks SS, Thompson RJ, Knisely AS. VPS33B mutation with ichthyosis, cholestasis, and renal dysfunction but without arthrogryposis: incomplete ARC syndrome phenotype. J Pediatr. 2006 Feb;148(2):269-71.